Beilstein J. Org. Chem.2015,11, 2370–2387, doi:10.3762/bjoc.11.259
as a renewable chemical feedstock, greatly enabling a sustainable carbon bio-economy.
Keywords: biocatalysis; carboxylase; CO2transformation; formate dehydrogenase; RuBisCO; Introduction
Depletion of fossil-fuel feedstocks and pollution resulting from their unsustainable processing and use
heterologous CO2 fixation reactions [21], that may then be coupled to an extensive array of metabolic pathways for the delivery of target compounds.
Biological strategies to increase CO2 reactivity
Energetic demand of CO2transformation
Most of the carbon associated with fossil-fuel based technologies will
number of carboxylases, phosphoanhydride bonds in ATP are hydrolysed to drive CO2transformation through various molecular mechanisms. For example, biotin carboxylase catalysed reactions proceed through electrophilic activation of CO2 to carboxyphosphate to facilitate an attack by a nucleophile [28].
In
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Graphical Abstract
Figure 1:
Biocatalytic routes for conversion of CO2 into compounds with carbon in the reduced oxidation state...